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The side effects of Mestinonpyridostigmineare most commonly related to overdosage and generally are of two varietiesmuscarinic and nicotinicAmong those in the former group are nauseavomitingdiarrheaabdominal crampsincreased peristalsisincreased salivationincreased bronchial secretionsmiosis and diaphoresisNicotinic side effects are comprised chiefly of muscle crampsfasciculation and weaknessMuscarinic side effects can usually be counteracted by atropinebut for reasons shown in the preceding section the expedient is not without dangerAs with any compound containing the bromide radicala skin rash may be seen in an occasional patientSuch reactions usually subside promptly upon discontinuance of the medication.

NOTEFor information on a diagnostic test for myasthenia gravisand for the evaluation and stabilization of therapyplease see product literature on Tensilonedrophonium chloride

For detailed information on the management of patients with myasthenia gravisthe physician is referred to one of the excellent reviews such as those by Osserman and Genkins2 Grob 3 or Schwab4,5.

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